Interleukln 5 Synthesis by Eosinophils: Association with Granules and Immunoglobulln-dependent Secretion
نویسندگان
چکیده
From the *Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, 59019 Lille, France; Mnatomie et Cytologie Pathologiques, H#pital Calmette, Centre Hospitalier Rigional Unitcrsitaire (CHRU), 59000 Lille, France; $Service de Gastroentdmlogie, HOpital Huriez, CHRU, 59000 Lille, France; IID3partement d'Immunologig H~pital Erasme, BI070 Bnaxelles, Belgium; and 82 Research Gent, B9000 Gent, Belgium
منابع مشابه
Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion
Interleukin 5 (IL-5) is the main factor that promotes the terminal differentiation of eosinophil progenitors (as indicated by colony formation assays), and enhances the effector capacity of mature eosinophils. IL-5 is produced by T lymphocytes, CD4-/CD8- and mast cells and recently, messenger (m)RNA of this cytokine has been identified in eosinophils from patients with coeliac disease, asthma, ...
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Eosinophils derive from the bone marrow and circulate at low levels in the blood in healthy individuals. These granulated cells preferentially leave the circulation and marginate to tissues, where they are implicated in the regulation of innate and adaptive immunity. In diseases such as allergic inflammation, eosinophil numbers escalate markedly in the blood and tissues where inflammatory foci ...
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